Publications

Heritability of sleep architecture based on home polysomnography

Journal of Sleep Research

Article

heritability

sleep

PSG

This study assessed the heritability of polysomnography sleep measures in 648 participants from the Baependi Heart Study in Brazil. It found that genetic factors influence total sleep time, non-REM sleep stages (especially N3), and the apnea-hypopnea index, but not REM sleep. These findings support the feasibility of future genetic studies on sleep traits.

Mário A. Leocadio-Miguel, Tâmara P Taporoski, Felipe Beijamini, Francieli S Ruiz, Andrea RVR Horimoto, Alexandre C Pereira, Kristen L Knutson, Malcolm von Schantz

Cycling reduces the entropy of neuronal activity in the human adult cortex

Article

entropy

cortical activity

EEG

This study used recurrence entropy to assess brain complexity (BC) in EEG signals during rest and cycling in 24 healthy adults. Results showed lower entropy during cycling, suggesting that repetitive movement reduces brain complexity due to continuous sensory feedback and streamlined sensorimotor processing.

Iara Beatriz Silva Ferré, Gilberto Corso, Gustavo Zampier dos Santos Lima, Sergio Roberto Lopes, Mario André Leocadio-Miguel, Lucas G. S. França, Thiago de Lima Prado, John Fontenele Araújo

Neonatal brain dynamic functional connectivity in term and preterm infants and its association with early childhood neurodevelopment

Nature Communications

Article

brain

MRI

dynamics

This study examines dynamic functional connectivity in newborns using fMRI, revealing six transient brain connectivity states present at birth. It finds that preterm infants exhibit atypical connectivity patterns, which are linked to social, sensory, and repetitive behaviors at 18 months, suggesting early neurodevelopmental differences.

Lucas G. S. França, Judit Ciarrusta, Oliver Gale-Grant, Sunniva Fenn-Moltu, Sean Fitzgibbon, Andrew Chew, Shona Falconer, Ralica Dimitrova, Lucilio Cordero-Grande, Anthony N. Price, Emer Hughes, Jonathan O’Muircheartaigh, Eugene Duff, Jetro J. Tuulari, Gustavo Deco, Serena J. Counsell, Joseph V. Hajnal, Chiara Nosarti, Tomoki Arichi, A. David Edwards, Grainne McAlonan, Dafnis Batalle

Hemodialysis-induced chronodisruption and chronotype distribution in patients with chronic kidney disease

The Journal of Biological and Medical Rhythm Research

Article

hemodialisis

sleep

This study examined circadian rhythm disruptions in 165 hemodialysis patients, finding that 40.6% experienced hemodialysis-induced chronodisruption (HIC). A morning chronotype was more prevalent in CKD patients than in the general population. HIC and chronotype were linked to quality of life but not sleep quality, highlighting potential implications for patient well-being.

Patrícia Pereira Nunes, Caroline Meneses Resende, Ellen Dayanne Barros Silva, Deryc Cleyner Piones Bastos, Max Luiz Mendes Ramires Filho, Mário A. Leocadio-Miguel, Mario Pedrazzoli, Manoel Alves Sobreira-Neto, Tiago Gomes de Andrade, Lívia Leite Góes Gitaí, Flávio Teles

Use of sleep quality questionary and cortisol awakening response as complementary tools for the evaluation of major depression progression

Current Psychology

Article

cortisol

sleep

major depression

This study examined the relationship between sleep quality and cortisol awakening response (CAR) across major depression severity. Patients with treatment-resistant depression had poorer sleep and a blunted CAR, while those with mild depression showed worse sleep but an elevated CAR compared to healthy controls. Sleep quality, particularly sleep medication use and sleep efficiency, was a strong predictor of depression severity, highlighting its clinical relevance for assessing and managing major depressive disorder.

Lucas Henrique Sousa Freitas Torres, Ysla Kallena Macedo Medeiros, Geovan Menezes de Sousa, Hector Quinones Vargas, Ana Cecília de Menezes Galvão, Raíssa Nóbrega de Almeida, Mário A. Leocadio-Miguel, Bruno Lobão-Soares, Fernanda Palhano-Fontes, Dráulio Barros de Araujo, Nicole Leite Galvão-Coelho

Blue light exposure-dependent improvement in robustness of circadian rest-activity rhythm in aged rats

Article

aging

SCN

Rest-activity rhythm

This study investigated the effects of blue light therapy on circadian rhythms in aging rats. Exposure to blue light for 14 days improved locomotor rhythmicity, increasing amplitude, robustness, and phase advance while enhancing rest-phase consolidation. However, these benefits required continuous exposure. The findings suggest that blue light may help mitigate age-related circadian dysfunctions, though further research is needed to understand the underlying neural mechanisms.

Eryck Holmes A. Silva, Nelyane Nayara M. Santana, Narita Renata M. Seixas, Lyzandro Lucas F. Bezerra, Maria Milena O. Silva, Sâmarah F. Santos, Jeferson S. Cavalcante, Mário A. Leocadio-Miguel, Rovena Clara Engelberth